![]() ![]() Lactated Ringer's injection may increase your risk of having hyperkalemia (high potassium level in the blood). ![]() Talk with your doctor right away if you have a decrease in the amount of urine output, noisy, rattling breathing, trouble with breathing, swelling of the fingers, hands, feet, or lower legs, troubled breathing at rest, or weight gain. This medicine may cause fluid overload and overhydration, which can lead to pulmonary congestion (fluid in the lungs) and swelling. Check with your doctor right away if you have loss of consciousness, confusion, seizures, decreased urine output, dizziness, fast or irregular heartbeat, headache, increased thirst, muscle pain or cramps, trouble breathing, swelling of the face, ankles, or hands, or unusual tiredness or weakness. ![]() This medicine may cause hyponatremia (low sodium level in the blood), which can lead to acute hyponatremic encephalopathy. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Patients older than 28 days of age should not receive this medicine together with ceftriaxone in the same infusion line. It is concluded that in the CHT model used in this study, the large volume of lactated Ringer's solution did not affect blood electrolyte concentration, neurological outcome, or formation of brain edema, whereas smaller volumes of 5% dextrose solution increased blood glucose and decreased blood sodium concentrations, did not affect plasma osmolality, and had a deleterious effect on neurological outcome.Children 28 days of age or younger (neonates) should not receive this medicine together with ceftriaxone. Although blood glucose concentration increased to 1126 +/- 102 g% (mean +/- standard deviation) and 1568 +/- 283 g% and blood sodium concentration decreased to 110.4 +/- 4.6 mEq/L and 92.0 +/- 5.2 mEq/L in the groups treated with 0.08 ml/g and 0.16 ml/g of 5% dextrose solution, respectively, plasma osmolality was normal and no significant difference could be found between the brain tissue specific gravity of animals in the nontreated and 5% dextrose treatment groups. None of the groups treated with 0.16 ml/g 5% dextrose solution survived 24 hours. The groups treated with 5% dextrose solution showed a significantly higher mortality rate, but the NSSs of the surviving rats were not different from controls. In addition, the mortality rate after CHT was not increased by administration of lactated Ringer's solution. The NSS, extent of edema, blood electrolyte concentrations, and plasma osmolality in the groups treated with lactated Ringer's solution were not significantly different from those values in the nontreated groups. Fluids were administered beginning 1 hour after scalp incision or CHT. ![]() One hundred eighteen rats, which survived halothane anesthesia and CHT, were randomly assigned to one of 15 experimental groups. The purposes of this study were to determine whether rapid infusion of a large volume of lactated Ringer's solution could be given after CHT without increasing mortality or brain edema or producing electrolyte disturbances, and whether small volumes of 5% dextrose could be infused with few or none of the deleterious effects expected from large volumes of 5% dextrose. In the present study the authors examined the effect of rapid infusion (30 minutes) of smaller volumes of 5% dextrose (0.08 ml/g and 0.16 ml/g) and of 0.25 ml/g lactated Ringer's solution on blood electrolyte concentrations, plasma osmolality, brain edema, and NSS. Rapid infusion of the same volume of 5% dextrose solution decreased blood sodium concentration, increased edema, and decreased NSS following CHT. Rapid infusion of 0.25 ml/g of 0.9% saline over 30 minutes has been shown to have no effect on electrolyte balance, neurological severity score (NSS), or brain edema, following closed head trauma (CHT). ![]()
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